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Melissa Geddie, Ph.D., is the SVP of Drug Discovery at Diagonal Therapeutics. She has over 15 years of industry experience in the discovery and development of innovative antibody drugs. Melissa has also worked at Biogen, Kiniksa Pharmaceuticals, and Merrimack Pharmaceuticals in their early discovery groups. She was a postdoctoral fellow at the Whitehead Institute and received her Ph.D. in Biochemistry from Emory University. 

Clustering antibodies present a compelling approach to treat diseases driven by defective signaling pathways, but their discovery has been limited by the difficulty of identifying epitopes that successfully trigger receptor signaling. Using a combination of physics-aware deep learning and experimental approaches, we successfully generated bispecific agonist antibodies against ALK1 and BMPRII that activate the signaling complex and treated HHT pathologies in various mouse models. Our approach has shown to be applicable across diseases and targets.