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>Matthew Romei

About The Speaker

Matthew Romei

Senior Scientist, Dualitas Therapeutics, Inc

Matthew Romei

Dr. Romei is currently a Senior Scientistfocusing on biotherapeutic engineering at Dualitas Therapeutics in South San Francisco.He received his Bachelor of Science in Chemistry and Biochemistry from Haverford College and his PhD in Chemistry from Stanford University. Before joining Dualitas, he completed a postdoctoral fellowship at Genentech in Antibody Engineering under the guidance of Dr. Greg Lazar.

Antibody Architectures and Interfaces: Nature’s Guide to Biotherapeutic Engineering

Monoclonal antibodies have delivered enormous impact for the treatment of diseases and consequently have become one of the most highly engineered protein families. The most clinically successful enhancements to antibody drugs have been modest mutational modifications of natural interactions. A corollary is that the discovery of new antibody interfaces creates new opportunities for biotherapeutic engineering. Our work capitalizes on naturally occurring interactions within antibodies, in a manner that relies on their high sequence and structural homology for design, to create new and generalizable tools for optimization of this important biotherapeutic class.

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